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1996-02-27
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Document 0709
DOCN M9630709
TI A sonographic-pathological correlation of liver biopsies in patients
with the acquired immune deficiency syndrome (AIDS).
DT 9603
AU Beale TJ; Wetton CW; Crofton ME; Department of Radiology, St Mary's
Hospital, London, UK.
SO Clin Radiol. 1995 Nov;50(11):761-4. Unique Identifier : AIDSLINE
MED/96080102
AB The liver is commonly involved in patients with AIDS and a first line
investigation for hepatic dysfunction is liver ultrasound (US) which is
often abnormal. It is unclear how these US abnormalities correlate with
the underlying pathological processes. A retrospective study was
performed in 48 patients with HIV disease who had undergone both liver
biopsy and hepatic (US), correlating the findings. Only 25% of patients
had an entirely normal liver (US) examination and only 10% patients had
a normal liver biopsy. The commonest sonographic abnormalities was a
diffusely hyperechoic liver seen in 46% of patients and this correlated
with steatosis. Forty-four percent of biopsies contained more than one
histological abnormality including granulomas, inflammation, steatosis
or siderosis. In addition clinically unsuspected pathology was revealed
in five of the cases of mycobacterial infection and in three cases of
lymphoma. The combination of multiple histological abnormalities,
unsuspected pathology, and the altered immune response in this group
makes the US findings even less specific than in non-AIDS patients. We
recommend that liver biopsy should remain an essential and early part of
the management of AIDS patients.
DE Acquired Immunodeficiency Syndrome/*PATHOLOGY/*ULTRASONOGRAPHY Adult
Aged AIDS-Related Opportunistic Infections/COMPLICATIONS Biopsy,
Needle Female Human Liver/*PATHOLOGY Liver
Diseases/*PATHOLOGY/*ULTRASONOGRAPHY Male Middle Age Mycobacterium
Infections/COMPLICATIONS Retrospective Studies Sensitivity and
Specificity JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).